Canagliflozin
Canagliflozin is a new type of insulin that significantly reduced the risk of death from cardiovascular disease and hospitalization for heart failure. There are several other benefits to be noted with this drug. These include reduced body weight, protection against progression of albuminuria, and reduced CVD risk. If you’re considering starting this medication, read on for more information. But before you begin, remember that canagliflozin is not for everyone.
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Nonglycemic improvements
A new study suggests that canagliflozin may protect cardiovascular health in patients with type 2 diabetes. The researchers studied patients whose diabetes was controlled by diet and exercise, and found that canagliflozin reduced the risk of cardiovascular events, heart failure hospitalization, and visceral adipocyte hypertrophy. These findings are consistent with the promising results from the EMPA-REG OUTCOME trial, published in J Clin Hypertens.
Another recent study has shown that canagliflozin reduces insulin resistance by improving b-cell function. Although these two mechanisms have similar effects, it is not yet clear if canagliflozin is effective in decreasing insulin resistance and enhancing b-cell function. The researchers note that canagliflozin and glucagons may have distinct mechanisms for lowering blood glucose.
Empagout Outcome trial also showed that canagliflozin improves cardiovascular outcomes in type 2 diabetic patients. This study showed that canagliflozin improves kidney function in patients with high-risk cardiovascular disease. Canagliflozin and empagliflozin showed comparable effects on the heart in a type 2 diabetes population.
Body weight reduction
A recent study has found that canagliflozin reduces body weight in T2DM patients, and may therefore have important health benefits. In addition to improving glycemic control, the drug also reduces uric acid levels.The findings from this study also showed that canagliflozin treatment was associated with reduced body weight and waist circumference. Patients who took canagliflozin exhibited significant weight loss and reduction in HbA1c levels. In addition, canagliflozin reduced systolic blood pressure, and had significant reductions in HbA1c.
The results of this study indicated that canagliflozin reduced body weight and systolic blood pressure in adults with T2DM. Unlike other GLP-1 RAs, canagliflozin did not cause a dose-related effect on blood glucose. Despite this, it decreased the amount of subcutaneous and visceral fat, a factor in the initiation of diabetes.
The drug inhibits the production of SGLT2 in the kidney, and as a result, reduces body weight in T2DM patients. These findings support previous studies that canagliflozin reduces liver weight and reduces steatosis in obese patients.
Protection against progression of albuminuria
The association between cardiovascular events and protection against progression of albuminuria remains unclear. However, lowering albuminuria levels may provide some protection against cardiovascular events. Moreover, albuminuria is inexpensive and easily measured, making it a useful marker for monitoring cardiovascular risk and effectiveness of cardioprotective therapy.
The effect of canagliflozin on kidney disease outcome was not significantly different across treatment intensity categories. However, the drug’s effect on eGFR was not significantly different in HbA 1c subgroups. These results suggest that the drug may not provide significant protection against progression of albuminuria.
The study also found that canagliflozin decreased the risk of cardiovascular death, nonfatal myocardial infarction, and stroke. The benefit was consistent across a range of renal function categories and subgroups, but was borderline higher in patients with a history of amputation.
Researchers from Janssen Research & Development, LLC, a pharmaceutical company, funded the trial and were involved in the design and conduct of the study. In addition, they developed the canagliflozin drug with collaboration from the Mitsubishi Tanabe Pharma Corporation. This review was supported by a grant from Janssen to fund the study.
However, the drug does come with a number of side effects. The most common of these is urinary tract infection, polyuria, and volume depletion. Hypoglycemia is also a potential side effect. Researchers recommend monitoring the drug for hypoglycemia to detect any hypoglycemic effects.
Researchers concluded that canagliflozin significantly reduced the risk of cardiovascular events, both overall and for individual component outcomes. This finding is consistent with findings from the CANVAS Program. The results also supported the fact that the drug reduced risk of major cardiovascular events across a range of patient populations, including those with renal impairment and type 2 diabetes.
Canagliflozin Protection against progression of kidney disease
Recent research has indicated that certain proteins may protect against the progression of kidney disease. These proteins are angiopoietin-1, fibroblast growth factor 20, and tumor necrosis factor ligand superfamily member 12. Researchers are currently developing protocols for the measurement of these proteins in clinical settings. These proteins may one day help physicians identify patients who are at risk of progression.
Kidneys filter wastes and excess fluids from the blood and excrete these wastes in the urine. Advanced stages of the condition can result in dangerous levels of wastes, fluids, and electrolytes in the body. Many people are unaware of having kidney disease until it has advanced to end-stage kidney failure.
Keeping a healthy blood pressure is an important step in slowing the progression of kidney disease. It is particularly important for people with diabetes or proteinuria. Lifestyle changes, such as exercising regularly, meditating, and limiting salt intake, can help reduce blood pressure and prevent kidney failure. Your doctor may also prescribe blood pressure medicine if needed. If you suffer from high blood pressure, you should monitor your blood pressure regularly to prevent any complications.
